Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model.

  title={Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model.},
  author={Talmage D. Egan and S Kuramkote and G Gong and J Zhang and Scott W. McJames and P L Bailey},
  volume={91 1},
BACKGROUND It is common clinical practice to administer reduced doses of opioid to patients suffering from hemorrhagic shock to minimize adverse hemodynamic consequences and to prevent prolonged opioid effect However, the scientific foundation supporting this practice is not well established. The aim of this study was to test the hypothesis that hemorrhagic shock alters both the distribution and clearance of opioids using fentanyl in a porcine isobaric hemorrhage model. METHODS Eighteen pigs… CONTINUE READING