Fentanyl concentrations in brain and serum during respiratory acid--base changes in the dog.

@article{Ainslie1979FentanylCI,
  title={Fentanyl concentrations in brain and serum during respiratory acid--base changes in the dog.},
  author={S G Ainslie and John H Eisele and G Corkill},
  journal={Anesthesiology},
  year={1979},
  volume={51 4},
  pages={293-7}
}
It is a clinical impression that less fentanyl is needed for anesthesia during hyperventilation and hypocarbia. If true, it might be due to both increased penetration of fentanyl, a highly lipid-soluble agent, into the brain and increased brain tissue binding. Serum and brain concentrations of fentanyl were determined in dogs anesthetized with halothane during normocarbia, hypocarbia by hyperventilation, and hypercarbia by addition of CO2 to the inspired mixture. Fentanyl, 12.5 micrograms/kg… CONTINUE READING

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