Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl.

@article{Daniel1998FentanylAT,
  title={Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl.},
  author={M Daniel and Richard B. Weiskopf and Meher Noorani and Edmond I. Eger},
  journal={Anesthesiology},
  year={1998},
  volume={88 1},
  pages={43-9}
}
BACKGROUND Heart rate (HR) or mean arterial blood pressure (MAP) may increase in response to incision despite the absence of a motor response. The authors hypothesized that the MAC-BAR (minimum alveolar concentration of an anesthetic that blocks adrenergic response to incision) for isoflurane would exceed that for desflurane, and that fentanyl would decrease the MAC-BAR for each anesthetic in a dose-dependent manner. METHODS Seventy-one patients were randomly allocated to one of six groups… CONTINUE READING

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