Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner.

@article{Daijo2011FentanylAH,
  title={Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner.},
  author={Hiroki Daijo and Shinichi Kai and Tomoharu Tanaka and Takuhiko Wakamatsu and Shun Kishimoto and Kengo Suzuki and Hiroshi Harada and Satoshi Takabuchi and Takehiko Adachi and Kazuhiko Fukuda and Kiichi Hirota},
  journal={European journal of pharmacology},
  year={2011},
  volume={667 1-3},
  pages={144-52}
}
Hypoxia-inducible factor 1 (HIF-1) is the main transcription factor responsible for hypoxia-induced gene expression. Perioperative drugs including anesthetics have been reported to affect HIF-1 activity. However, the effect of fentanyl on HIF-1 activity is not well documented. In this study, we investigated the effect of fentanyl and other opioids on HIF-1 activity in human SH-SY5Y neuroblastoma cells, hepatoma Hep3B cells, lung adenocarcinoma A549 cells and mice. Cells were exposed to fentanyl… CONTINUE READING
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