Fentanyl Formulations in the Management of Pain: An Update

@article{Schug2017FentanylFI,
  title={Fentanyl Formulations in the Management of Pain: An Update},
  author={Stephan Alexander Schug and Sonya Ting},
  journal={Drugs},
  year={2017},
  volume={77},
  pages={747-763}
}
Fentanyl is a synthetic, highly selective opioid with many desirable physicochemical properties, including a high lipophilicity and predictable pharmacokinetics. These properties have an established record in the management of pain in a variety of settings, particularly acute pain and breakthrough cancer pain. Fentanyl was initially developed for parenteral use; however, this is invasive and impractical in the outpatient setting. Unfortunately, the high first-pass metabolism of fentanyl makes… CONTINUE READING
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