Fentanyl‐induced Rigidity and Unconsciousness in Human Volunteers Incidence, Duration, and Plasma Concentrations

  title={Fentanyl‐induced Rigidity and Unconsciousness in Human Volunteers Incidence, Duration, and Plasma Concentrations},
  author={James B. Streisand and Peter Lawrence Bailey and Leon LeMaire and Michael A. Ashburn and Stephen D. Tarver and John R. Varvel and Theodore H. Stanley},
BackgroundMuscle rigidity frequently accompanies induction of anesthesia with opioids. The authors sought to determine whether unconsciousness and amnesia occur when humans develop rigidity and apnea after intravenous fentanyl (without other concomitant anesthetics). MethodsThe Incidence and duration of rigidity and level of consciousness were evaluated and associated plasma concentrations of fentanyl were measured in 12 healthy adult male volunteers given only intravenous fentanyl. Fentanyl… 

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