Fenspiride and membrane transduction signals in rat alveolar macrophages.

@article{Feray1997FenspirideAM,
  title={Fenspiride and membrane transduction signals in rat alveolar macrophages.},
  author={Jean Feray and Kamiar Mohammadi and Karima Taouil and John Brunet and Ricardo P. Garay and Patrick Hannaert},
  journal={Biochemical pharmacology},
  year={1997},
  volume={54 2},
  pages={
          293-7
        }
}
Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophages, high fenspiride concentrations (1 mM) were required to inhibit the calcium signals evoked by the calcium agonist Bay K8644 or by ionomycin. Moreover, fenspiride (1 mM) was a poor inhibitor of the cell membrane depolarization induced by… 

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