Fenretinide-induced caspase 3 activity involves increased protein stability in a mechanism distinct from reactive oxygen species elevation.

@article{Dipietrantonio2000FenretinideinducedC3,
  title={Fenretinide-induced caspase 3 activity involves increased protein stability in a mechanism distinct from reactive oxygen species elevation.},
  author={A Dipietrantonio and T. C. Hsieh and Germ{\'a}n Juan and Frank Traganos and Zbigniew Darzynkiewicz and Joseph M.W. Wu},
  journal={Cancer research},
  year={2000},
  volume={60 16},
  pages={4331-5}
}
Fenretinide (4-HPR) is a synthetic retinoid that displays a broad range of biological effects and has also demonstrated clinical efficacy as a chemopreventative agent. One cellular activity of 4-HPR is its ability to induce apoptosis. This effect has been proposed to relate to changes in intracellular reactive oxygen species. We show herein that a 1-h treatment of HL-60 cells with 4-HPR led to a dose-dependent increase in hydroperoxides. Pretreatment of cells with the antioxidant vitamin C… CONTINUE READING
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