Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.

  title={Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.},
  author={Claudine Guilbault and Juan Bautista de Sanctis and Gabriella Wojewodka and Zienab Saeed and Claude Joseph Lachance and Thomas A A Skinner and Regina Maria Vilela and Stan Kubow and Larry C. Lands and Mari{\'a}n Hajd{\'u}ch and Elias Matouk and Danuta Radzioch},
  journal={American journal of respiratory cell and molecular biology},
  volume={38 1},
Chronic and persistent lung infections cause the majority of morbidity and mortality in patients with cystic fibrosis (CF). Galactosyl ceramide has been previously shown to be involved in Pseudomonas internalization. Therefore, we assessed ceramide levels in the plasma of patients with CF and compared them to healthy volunteers using high-performance liquid chromatography followed by mass spectrometry. Our results demonstrate that patients with CF display significantly lower levels of several… CONTINUE READING
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