Fenretinide (4-HPR) Targets Caspase-9, ERK 1/2 and the Wnt3a/β-Catenin Pathway in Medulloblastoma Cells and Medulloblastoma Cell Spheroids

@inproceedings{Bassani2016FenretinideT,
  title={Fenretinide (4-HPR) Targets Caspase-9, ERK 1/2 and the Wnt3a/β-Catenin Pathway in Medulloblastoma Cells and Medulloblastoma Cell Spheroids},
  author={Barbara Bassani and Desir{\'e}e Bartolini and Arianna Pagani and Elisa Principi and Massimo Zollo and Douglas M Noonan and Adriana Albini and Antonino Bruno},
  booktitle={PloS one},
  year={2016}
}
Medulloblastoma (MB), a neuroectodermal tumor arising in the cerebellum, represents the most frequent childhood brain malignancy. Current treatments for MB combine radiation and chemotherapy and are often associated with relevant side effects; novel therapeutic strategies are urgently needed. N-(4-Hydroxyphenyl) retinamide (4-HPR, fenretinide), a synthetic… CONTINUE READING