Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice.

@article{Oosterveer2009FenofibrateSI,
  title={Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice.},
  author={Maaike H. Oosterveer and Aldo Grefhorst and Theo H. van Dijk and Rick Havinga and Bart Staels and Folkert Kuipers and Albert K. Groen and Dirk-Jan Reijngoud},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 49},
  pages={34036-44}
}
A growing body of evidence indicates that peroxisome proliferator-activated receptor alpha (PPARalpha) not merely serves as a transcriptional regulator of fatty acid catabolism but also exerts a much broader role in hepatic lipid metabolism. We determined adaptations in hepatic lipid metabolism and related aspects of carbohydrate metabolism upon treatment of C57Bl/6 mice with the PPARalpha agonist fenofibrate. Stable isotope procedures were applied to assess hepatic fatty acid synthesis, fatty… CONTINUE READING