Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.

@article{Lee2007FenofibrateRI,
  title={Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.},
  author={J. William Lee and Poonam J. Bajwa and Monica J. Carson and Daniel R Jeske and Yingzi Cong and Charles O Elson and Christian H. Lytle and Daniel S. Straus},
  journal={Gastroenterology},
  year={2007},
  volume={133 1},
  pages={108-23}
}
BACKGROUND & AIMS Interleukin-10 knockout (IL-10(-/-)) mice spontaneously develop colitis characterized by T-helper cell type 1-polarized inflammation. We tested the possible therapeutic activity of the peroxisome proliferator-activated receptor alpha (PPARalpha) ligand fenofibrate, and the PPARdelta ligand GW0742, in IL-10(-/-) mice and investigated the cellular/molecular mechanisms for fenofibrate action. METHODS The effect of fenofibrate or GW0742 on the progression of colitis in C3H.IL-10… CONTINUE READING