Fenofibrate raw materials: HPLC methods for assay and purity and an NMR method for purity.

@article{Lacroix1998FenofibrateRM,
  title={Fenofibrate raw materials: HPLC methods for assay and purity and an NMR method for purity.},
  author={Pascal Lacroix and Brian A Dawson and Raymond W. Sears and Dana Black and Terry D. Cyr and Jean {\'E}thier},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1998},
  volume={18 3},
  pages={383-402}
}
HPLC methods for drug content and HPLC and NMR methods for related compounds in fenofibrate raw materials were developed. The HPLC methods resolved 11 known and six unknown impurities from the drug. The HPLC system was comprised of a Waters Symmetry ODS column (100 x 4.6 mm, 3.5 microm), a mobile phase consisting of acetonitrile water trifluoroacetic acid 700/300/l (v/v/v) at a flow rate of 1 ml min(-1). and a UV detector set at 280 nm. Minimum quantifiable amounts were about 0.1% for three of… CONTINUE READING

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