Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway.

Abstract

Recent clinical trials demonstrated that PPARα agonist fenofibrate reduces cardiovascular events, including limb amputation in people with type 2 diabetes. Here, we investigated whether fenofibrate modulates the revascularization process in a mouse model of hindlimb ischemia. Treatment with fenofibrate led to acceleration of revascularization of ischemic… (More)
DOI: 10.1152/ajpendo.00284.2010

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