Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice.

@article{Vera2005FenofibratePT,
  title={Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice.},
  author={Trinity Vera and Montoya Taylor and Quinn C Bohman and Averia K Flasch and Richard J. Roman and David E Stec},
  journal={Hypertension},
  year={2005},
  volume={45 4},
  pages={730-5}
}
Previous studies have indicated that the production of 20-hydroxyecisatatraenoic acid (20-HETE) is similar in the liver of C57/B6 mice and rats, but the renal production of 20-HETE is very low in this strain of mice. The present study examined the effects of induction of the renal production of 20-HETE with fenofibrate (FF) on the development of angiotensin II (Ang II)-dependent hypertension in C57BL/6J mice. The mice were divided into 4 groups and treated with vehicle (control), FF (90 mg/kg… CONTINUE READING