Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.

  title={Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.},
  author={Adaliene Versiani de Matos Ferreira and Gleydes Gambogi Parreira and Laura Cristina Jardim P{\^o}rto and Erica Guihen Mario and Helen Lima Delpuerto and Almir de Sousa Martins and Leida Maria Botion},
  journal={Life sciences},
  volume={82 15-16},
The experiments performed in this report were designed to investigate the mechanisms involved in the metabolic alterations associated with orotic acid-induced hepatic steatosis and the effect of fenofibrate, a stimulant of peroxisome proliferators-activated receptor alpha (PPARalpha), on these alterations. Male Wistar rats were divided into three experimental groups: 1) fed a balanced diet (C); 2) fed a balanced diet supplemented with 1% orotic acid (OA); 3) fed OA diet containing 100 mg.kg(-1… CONTINUE READING