Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1.

@article{Lan2005FenofibrateIA,
  title={Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1.},
  author={Debin Lan and David L Silver},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 24},
  pages={23390-6}
}
Fibrate drugs improve cardiovascular health by lowering plasma triglycerides, normalize low density lipoprotein levels, and raise high density lipoprotein (HDL) levels in patients with dyslipidemias. The HDL-raising effect of fibrates has been shown to be due in part to an increase in human apolipoprotein AI gene expression. However, it has recently been shown that fibrates can affect HDL metabolism in mouse by significantly decreasing hepatic levels of the HDL receptor scavenger receptor B-I… CONTINUE READING
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