Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.

@article{Wilk2012FenofibrateinducedNT,
  title={Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro.},
  author={Anna Wilk and Katarzyna Urbańska and Maja Grabacka and Jennifer Mullinax and Cezary Marcinkiewicz and David Impastato and John J Estrada and Krzysztof Reiss},
  journal={Cell cycle},
  year={2012},
  volume={11 14},
  pages={2660-71}
}
Anti-neoplastic potential of calorie restriction or ligand-induced activation of peroxisome proliferator activated receptors (PPARs) has been demonstrated in multiple studies; however, mechanism(s) by which tumor cells respond to these stimuli remain to be elucidated. One of the potent agonists of PPARα, fenofibrate, is a commonly used lipid-lowering drug with low systemic toxicity. Fenofibrate-induced PPARα transcriptional activity is expected to shift energy metabolism from glycolysis to… CONTINUE READING
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