Fenofibrate-induced decrease of expression of CYP2C11 and CYP2C6 in rat.

@article{Veea2011FenofibrateinducedDO,
  title={Fenofibrate-induced decrease of expression of CYP2C11 and CYP2C6 in rat.},
  author={Rostislav Ve{\vc}eřa and Alice Zachařov{\'a} and Jan Orolin and Jan Strojil and Nina Skottov{\'a} and Pavel Anzenbacher},
  journal={Biopharmaceutics & drug disposition},
  year={2011},
  volume={32 8},
  pages={482-7}
}
This short communication is aimed to investigate whether the widely used hypolipidemic drug fenofibrate affects CYP2C11 and CYP2C6 in rats, both counterparts of human CYP2C9, known to metabolise many drugs including S-warfarin and largely used non-steroidal antiinflammatory drugs such as ibuprofen, diclofenac and others. The effects of fenofibrate on the expression of rat liver CYP2C11 and CYP2C6 were studied in both healthy Wistar rats and hereditary hypertriglyceridemic rats. Both strains of… CONTINUE READING

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