Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle.

@article{Dai2016FenofibrateIH,
  title={Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle.},
  author={F. Z. Dai and Tian Jiang and Ying-Ying Bao and Guanjun Chen and Li Chen and Qiu Kui Zhang and Yunxia Lu},
  journal={Life sciences},
  year={2016},
  volume={157},
  pages={158-67}
}
AIMS Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress and downstream inflammation in skeletal muscle tissues and cells. MAIN METHODS Female SD rats were randomly divided into groups receiving the standard chow diet (SCD), a high… CONTINUE READING