Fenofibrate, a peroxisome proliferator–activated receptor‐α agonist, exerts anticonvulsive properties

@article{Porta2009FenofibrateAP,
  title={Fenofibrate, a peroxisome proliferator–activated receptor‐$\alpha$ agonist, exerts anticonvulsive properties},
  author={Natacha Porta and Louis Vallée and C{\'e}cile Lecointe and Emmanuel Bouchaert and Bart Staels and R{\'e}gis Bordet and St{\'e}phane Auvin},
  journal={Epilepsia},
  year={2009},
  volume={50}
}
The underlying mechanisms of the ketogenic diet (KD) remain unknown. Involvement of peroxisome proliferator–activated receptor‐α (PPARα) has been suggested. The aim of this study was to assess the anticonvulsant properties of fenofibrate, a PPARα agonist. Wistar rats were fed at libitum during 14 days by regular diet, KD, regular diet containing 0.2% fenofibrate (F), or KD containing 0.2% fenofibrate (KD + F). Pentylenetetrazol (PTZ) threshold and latencies to the onset of status epilepticus… 
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