Fenmetozole in acute alcohol intoxication in man

  title={Fenmetozole in acute alcohol intoxication in man},
  author={H. Brian Mcnamee and Jack H. Mendelson and J Korn},
  journal={Clinical Pharmacology \& Therapeutics},
Forty healthy adult male volunteers were studied to determine the efficacy of fenmetozole to antagonize the effects of acute alcohol intoxication. Twenty subjects received placebo and 20 fenmetozole in dosage of 100 mg and 200 mg in a double‐blind paradigm. Pretreatment with fenmetozole failed to antagonize or attenuate cognitive, perceptual, motor and affective changes associated with acute alcohol intoxication. 
7 Citations
Combined effects of fenmetozole and ethanol
Fenmetozole alone impaired standing steadiness but improved mental performance in one test, and in combination, the subjective symptoms caused by fenetozole were additive with those of ethanol.
Amethystic Agents in the Treatment of Alcohol Intoxication
Amethystic agents represent only one class of substances or conditions that can antagonize the actions of alcohol (ethanol) and several situations in which many of the acute and long-term effects of ethanol can be blocked.
Alcohol and Human Behavior
There has been a rapid expansion of behavioral research on alcohol and alcoholism within the past 10 years. The relics of a complex mythology have begun to yield to empirical observations, and a
Index to Volume 17
  • G. Gillum
  • Environmental Science
    ASTIN Bulletin
  • 1987
ADAR, R. (See Reichert et al.), 612 ALLEN, A. T., Ill. (See Neeld et al.), 290 ALLEN, L. M., AND CREAVEN, P. J. Pharmacokinetics of ifosfamide, 492 ALVARES, A. P., KAPELNER, S., SASSA, S., AND
An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function
The antagonistic action of fenmetozole against ethanol would not seem to be related to a specific receptor interaction but rather may be the result of a physiological antagonism.
Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex.
The inconsistent pattern of "antagonist" interactions of these drugs with the behavioral actions of ethanol suggests that ethanol alters several neurochemical systems to produce its behavioral effects.


Propranolol and behavior of alcohol addicts after acute alcohol ingestion
Pretreatment with 10, 20, and 40 mg of propranolol 4 times a day for 3 consecutive days prior to alcohol administration failed to block or attenuate cognitive, perceptual, motor, and affective changes induced by acute alcohol intoxication.
Clinical trial of imidazoline (DH-524) as an anti-depressant.
  • C. ChienR. Kaplan
  • Medicine
    Current therapeutic research, clinical and experimental
  • 1971
Clinical trial of F enmetozole in acute alcohol intoxication 737
    Clinical trial of F enmetozole in acute alcohol intoxication 737 imidazoline ( DH - 524 ) as an antidepressant
    • Curr . Ther . Res .
    • 1971
    imidazoline (DH-524) as an antidepressant
    • Curr. Ther. Res
    • 1971
    Dow Chemical Company: Information for clinical investigators, DH-524