Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats.

@article{Ito2014FenitrothionAA,
  title={Fenitrothion action at the endocannabinoid system leading to spermatotoxicity in Wistar rats.},
  author={Yuki Ito and Motohiro Tomizawa and Himiko Suzuki and Ai Okamura and Katsumi Ohtani and Mari Nunome and Yuki Noro and Dong Wang and Tamie Nakajima and Michihiro Kamijima},
  journal={Toxicology and applied pharmacology},
  year={2014},
  volume={279 3},
  pages={
          331-7
        }
}
Organophosphate (OP) compounds as anticholinesterase agents may secondarily act on diverse serine hydrolase targets, revealing unfavorable physiological effects including male reproductive toxicity. The present investigation proposes that fenitrothion (FNT, a major OP compound) acts on the endocannabinoid signaling system in male reproductive organs, thereby leading to spermatotoxicity (sperm deformity, underdevelopment, and reduced motility) in rats. FNT oxon (bioactive metabolite of FNT… CONTINUE READING
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