Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.

  title={Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.},
  author={Jeanne M. Connolly and Marina Bakay and James T. Fulmer and Robert C. Gorman and Joseph H. Gorman and Mark A Oyama and Robert J. Levy},
  journal={The American journal of pathology},
  volume={175 3},
Serotonin (5HT) receptor signaling and 5HT-related agents, such as the anorexogen fenfluramine (Fen), have been associated with heart valve disease. We investigated the hypothesis that Fen may disrupt mitral valve interstitial cell (MVIC) homeostasis through its effects on mitogenesis and extracellular matrix biosynthesis. Normal and myxomatous mitral valves, both human and canine, were harvested, and primary MVIC cultures were established. 5HT caused increased phosphorylation of extracellular… CONTINUE READING
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