Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.

  title={Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.},
  author={Roger Martin Pinder and Rex N. Brogden and Phyllis R. Sawyer and Trevor M. Speight and Graeme S. Avery},
  volume={10 4},
Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. Controlled studies and clinical experience have shown that it possesses anorectic activity at least as good as that of other therapeutically useful drugs of its type, but like these drugs it has only a limited role in the overall management of obesity. Tolerance to the anorectic effects of fenfluramine may possibly develop more slowly than to other chemically related drugs in patients… 
Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial.
It is suggested that short term treatment with fenfluramine may have a role in the management of some patients with Prader-Willi syndrome, and could be used during periods when exposure to large amounts of food cannot be avoided and aggressive behaviour is particularly difficult to contain.
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Dexfenfluramine. Its place in weight control.
Dexfenfluramine, the dextrostereoisomer of fenfluramine, is a pure serotonin (5-hydroxytryptamine) agonist, apparently devoid of any additional antidopaminergic or sympathomimetic effects. The drug
A Historical Overview Upon the Use of Amphetamine Derivatives in the Treatment of Obesity
An overview of both the history, and the current status, of the use of amphetamine derivatives in the obesity pharmacotherapy is provided.
Obesity Part 2: Pharmacotherapy
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Dexfenfluramine Place in Weight Control
Summary Dexfenfluramine, the dextrostereoisomer of fenfluramine, is a pure serotonin (5-hydroxytryptamine) agonist, apparently devoid of any additional antidopaminergic or sympathomimetic effects.
Anti-Obesity Therapy: from Rainbow Pills to Polyagonists
The historical pharmacological approaches to treat obesity and glucose intolerance are focused on and how the knowledge obtained by these studies led to the discovery of unimolecular polypharmacology is described.
Fenfluramine as antiseizure medication for epilepsy
  • M. Gogou, J. Cross
  • Medicine, Psychology
    Developmental medicine and child neurology
  • 2021
Data from randomized clinical trials have shown a beneficial effect of fenfluramine, as an adjunct therapy, on seizure control for children with Dravet syndrome, though there is still uncertainty about the impact on neurodevelopment in these patients.
Anesthetic considerations for the new antiobesity medications.
There are several anesthetic considerations when providing anesthesia services for patients on the fenfluramine and phentermine regimen, and anesthesia providers must understand the potential risks involved when administering a general anesthetic to these patients.


Toxic and therapeutic effects of EMTP in obesity
Although EMTP appeared more effective than the placebo, its results were not dramatic (nor statistically significant) and the drug caused mild to moderately severe side effects in 25 of 36 patients whereas there were only mild complaints in 11 of 28 patients receiving the placebo.
Effect of Fenfluramine on Human Growth Hormone Release
Observations indicate that fenfluramine has a direct effect on pathways controlling growth hormone release and it is suggested that this action may have practical use in the medical treatment of acromegaly.
Effect of fenfluramine on appetite and lipid metabolism of the young ruminant.
Serum glucose was reduced for fed calves at all concentrations of drug as well as in fasted control and fasted drug-treated calves, thus suggesting that the plane of nutrition was the important factor.
Subjective effects of two anorexigenic agents fenfluramine and AN 448 in amphetamine-dependent subjects.
  • K. Götestam, L. Gunne
  • Psychology, Medicine
    The British journal of addiction to alcohol and other drugs
  • 1972
Summary Twenty-two amphetamine-dependent subjects, all imprisoned drug abusers, with a history of at least one year of intravenous abuse of central stimulants, were used for evaluation of the
Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle.
  • M. Kirby
  • Medicine
    British journal of clinical pharmacology
  • 1974
There is a considerable lack of agreement on whether the anti-obesity drug fenfluramine owes some of its weight-reducing properties to a direct effect on glucose uptake into peripheral tissue, but preliminary studies with human isolated skeletal muscle using 100 ng/ml of both compounds have confirmed this action in human tissue.
Hypoglycemic Action of Fenfluramine in Diabetes Mellitus
Blood glucose levels were lowered by fenfluramine in diabetics who were maintained on diet alone or diet plus tolbutamide without the risk of lactic acidosis and without any direct effect on insulin secretion.
Effects of caloric restriction and fenfluramine on weight loss and personality profiles of patients with long standing obesity.
Many patients neither required nor benefitted from the services of a dietitian, they could not be motivated to adhere to a low calorie diet, and those who received fenfluramine eventually became resistant to its anorectic effects.