Fenetylline: new results on pharmacology, metabolism and kinetics.

@article{Nickel1986FenetyllineNR,
  title={Fenetylline: new results on pharmacology, metabolism and kinetics.},
  author={Bernd Nickel and Georg Dr Niebch and Gernot Peter and A von Schlichtegroll and Ulrich Tibes},
  journal={Drug and alcohol dependence},
  year={1986},
  volume={17 2-3},
  pages={
          235-57
        }
}
In the fenetylline molecule, theophylline is covalently linked with amphetamine via an alkyl chain. The inclusion of amphetamine and results from early metabolic studies have led to speculation that fenetylline may be merely a prodrug for amphetamine and/or theophylline. Although previous studies are not consistent with this hypothesis, additional studies were conducted to comparatively evaluate the profiles of activity exhibited by fenetylline and its two postulated primary metabolites… Expand
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Fenfluramine was shown to decrease the toxicity of amphetamine in grouped mice while S 992 failed to show any protection in the same experimental conditions, and the interaction in an isolated preparation was studied. Expand
Vergleichende Untersuchungen über zentrale Wirkungen von Xanthinderivaten in Hinblick auf deren Stoffwechsel und Verteilung im Organismus
SummaryThe central actions of some methylated xanthines (caffeine, theobromine, theophylline) and of some aromatically substituted theophylline derivatives were investigated and correlated with theExpand
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