Fen1 mutations result in autoimmunity, chronic inflammation and cancers

@article{Zheng2007Fen1MR,
  title={Fen1 mutations result in autoimmunity, chronic inflammation and cancers},
  author={Li Zheng and Huifang Dai and Mian Zhou and Mei Li and Purnima Singh and Junzhuan Qiu and Walter M. K. Tsark and Qin Huang and Kemp H. Kernstine and Xuemei Zhang and Dongxin Lin and Binghui Shen},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={812-819}
}
Functional deficiency of the FEN1 gene has been suggested to cause genomic instability and cancer predisposition. We have identified a group of FEN1 mutations in human cancer specimens. Most of these mutations abrogated two of three nuclease activities of flap endonuclease 1 (FEN1). To demonstrate the etiological significance of these somatic mutations, we inbred a mouse line harboring the E160D mutation representing mutations identified in human cancers. Selective elimination of nuclease… 
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