Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage.

@article{Liu2001FemtomolarCO,
  title={Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage.},
  author={Bin Liu and Liya Qin and San Nan Yang and Brian C. Wilson and Yuan Hua Liu and Jau Shong Hong},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={298 3},
  pages={1133-41}
}
The hallmark of Parkinson's disease is the death of nigral dopaminergic neurons, and inflammation in the brain has been increasingly associated with the pathogenesis of this neurological disorder. Dynorphins are among the major opioid peptides in the striato-nigral pathway and are important in regulating dopaminergic neuronal activities. However, it is not clear whether dynorphins play a role in the survival of nigral dopaminergic neurons. We have recently demonstrated that lipopolysaccharide… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…