Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage.

@article{Li2005FemtomolarCO,
  title={Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage.},
  author={Guorong Li and Gang Cui and Nian-ssheng Tzeng and Shuxia Wei and Tongguang Wang and Michelle L. Block and Jau-Shyong Hong},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 6},
  pages={489-96}
}
Inflammation in the brain has increasingly been recognized to play an important role in the pathogenesis of several neurodegenerative disorders, including Parkinson's disease (PD). Progress in the search for effective therapeutic strategies that can halt this degenerative process remains limited. We previously showed that micromolar concentrations of dextromethorphan (DM), a major ingredient of widely used antitussive remedies, reduced the inflammation-mediated degeneration of dopaminergic… CONTINUE READING

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