Femtomolar DNA detection by parallel colorimetric darkfield microscopy of functionalized gold nanoparticles.

@article{Verdoold2011FemtomolarDD,
  title={Femtomolar DNA detection by parallel colorimetric darkfield microscopy of functionalized gold nanoparticles.},
  author={Remco Verdoold and Ron Gill and Felicia Ungureanu and Robert Jan Molenaar and Rob P. H. Kooyman},
  journal={Biosensors & bioelectronics},
  year={2011},
  volume={27 1},
  pages={77-81}
}
We introduce a sensing platform for specific detection of DNA based on the formation of gold nanoparticles dimers on a surface. The specific coupling of a second gold nanoparticle to a surface bound nanoparticle by DNA hybridization results in a red shift of the nanoparticle plasmon peak. This shift can be detected as a color change in the darkfield image of the gold nanoparticles. Parallel detection of hundreds of gold nanoparticles with a calibrated true color camera enabled us to detect… CONTINUE READING
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