Female steroid hormones regulate production of pro-inflammatory molecules in uterine leukocytes.

@article{Hunt1997FemaleSH,
  title={Female steroid hormones regulate production of pro-inflammatory molecules in uterine leukocytes.},
  author={Joan S. Hunt and Lance Miller and Katherine F. Roby and Jintao Huang and Jeralyn Sue Platt and B L DeBrot},
  journal={Journal of reproductive immunology},
  year={1997},
  volume={35 2},
  pages={87-99}
}
Estrogens and progesterone could be among the environmental signals that govern uterine immune cell synthesis of pro-inflammatory substances. In order to investigate this possibility, we first mapped expression of the inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha) genes in the leukocytes of cycling and pregnant mouse uteri, then tested the ability of estradiol-17 beta (E2) and progesterone to influence gene expression. Immunohistochemistry, in situ… CONTINUE READING

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