Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data

@article{Rasier2006FemaleSM,
  title={Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data},
  author={Gr{\'e}gory Rasier and Jorma Toppari and Anne-Simone Parent and Jean Pierre Bourguignon},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={254},
  pages={187-201}
}

Figures and Tables from this paper

Endocrine-Disrupting Compounds and Pubertal Development: The Effects of Environmental Compounds on the Timing of Puberty in Humans
TLDR
Animal and human data confirm perturbations in pubertal onset, tempo, and age of menarche with early-life exposures to EDCs.
Male pubertal development: are endocrine-disrupting compounds shifting the norms?
TLDR
The normal process of puberty in males is reviewed and human data that suggest potential perturbations in pubertal onset and tempo with early-life exposures to EDCs are summarized.
Endocrine Disruption and Reproductive Disorders:Impacts onSexually Dimorphic Neuroendocrine Pathways.
TLDR
This review focuses on endocrine disrupting compounds (EDCs), both naturally occurring and man-made, and summarizes how they interfere with the neuroendocrine system to adversely impact pregnancy outcomes, semen quality, age at puberty, and other aspects of human reproductive health.
The Influence of Endocrine Disruptors on Male Pubertal Timing
TLDR
In conclusion, animal and human data confirm perturbations in pubertal onset and attainment of late Pubertal stages with early-life exposures to EDCs.
Endocrine disrupters and possible contribution to pubertal changes.
Mechanisms of estrogenic endocrine disruption of female puberty and reproduction and functions of LHFPL2 on distal reproductive tract development
TLDR
Novel knowledge is provided about mechanisms of estrogenic endocrine disruption of female puberty and reproduction, as well as a genetic basis of distal reproductive tract development about wildtype and mutant LHFPL2 are provided.
Endocrine disruptors and abnormalities of pubertal development.
TLDR
There is increasing evidence for a link between prenatal development and pubertal onset, and the causal pathways and the molecular mechanisms that may link the Pubertal growth pattern of children born SGA, puberal development and endocrine-disrupting chemicals need further study.
...
...

References

SHOWING 1-10 OF 160 REFERENCES
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TLDR
Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Environmental endocrine disrupters and disorders of sexual differentiation.
  • J. Toppari
  • Biology, Medicine
    Seminars in reproductive medicine
  • 2002
TLDR
There is a growing group of chemicals that have weak estrogenic properties, but, in addition, there are several antiandrogenic compounds that have been shown to disturb sexual differentiation in experimental animals.
Environmental toxins: Exposure to bisphenol A advances puberty
TLDR
It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice.
Effects of Pesticides and Toxic Substances On Behavioral and Morphological Reproductive Development: Endocrine Versus Nonendocrine Mechanisms
TLDR
The fact that reproductive function (behavioral, biochemical, and morphological) can be altered via such a wide variety of mechanisms indicates that hazard identification in this area cannot rely solely on the detection of endocrine activity.
Sexual differentiation and environmental endocrine disrupters.
The Effect of Prenatal Exposure to the Phytoestrogen Genistein on Sexual Differentiation in Rats
TLDR
The results confirm that prenatal exposure to estrogens in the environment can influence sexual differentiation and dosage and timing of exposure during development appear to be important factors in genistein's ability to modify these endpoints.
Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice.
TLDR
Perinatal exposure to environmentally relevant BPA doses results in persistent alterations in mammary gland morphogenesis, of special concern is the increased terminal end bud density at puberty as well as the increased number of terminal ends reported previously in adult animals.
Developmental neurotoxicity of endocrine disrupters: focus on estrogens.
TLDR
Results indicate that intake of a sodium solution is sensitive to these estrogen mimics, and volume of the sexually dimorphic nucleus of the medial preoptic area was reduced by genistein, nonylphenol, and ethinyl estradiol exposure in males.
...
...