Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload.

@article{Fliegner2010FemaleSA,
  title={Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload.},
  author={D. Fliegner and Carola Schubert and Adam Penkalla and Henning Witt and Georgios Kararigas and Elke Dworatzek and Eike Staub and Peter Martus and Patricia Ruiz Noppinger and Ulrich Kintscher and Jan-{\AA}ke Gustafsson and Vera Regitz-Zagrosek},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={298 6},
  pages={R1597-606}
}
We investigated sex differences and the role of estrogen receptor-beta (ERbeta) on myocardial hypertrophy in a mouse model of pressure overload. We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ERbeta knockout (ERbeta(-/-)) mice. All mice were characterized by echocardiography and hemodynamic measurements and were killed 9 wk after surgery. Left ventricular (LV) samples were analyzed by microarray profiling, real-time RT-PCR, and histology… CONTINUE READING

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