Female reproductive steroids and neuronal excitability

  title={Female reproductive steroids and neuronal excitability},
  author={C. Finocchi and M. Ferrari},
  journal={Neurological Sciences},
  • C. Finocchi, M. Ferrari
  • Published 2011
  • Biology, Medicine
  • Neurological Sciences
  • Oestrogen and progesterone have specific receptors in the central nervous system and are able to regulate neuronal development and plasticity, neuronal excitability, mitochondrial energy production, and neurotransmitter synthesis, release, and transport. On neuronal excitability, estradiol and progesterone seem to have an opposite effect, with estradiol being excitatory and progesterone and its derivative allopregnanolone being inhibitory. Estradiol augments N-methyl-d-aspartate-mediated… CONTINUE READING
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