Female reproductive steroids and neuronal excitability
@article{Finocchi2011FemaleRS, title={Female reproductive steroids and neuronal excitability}, author={C. Finocchi and M. Ferrari}, journal={Neurological Sciences}, year={2011}, volume={32}, pages={31-35} }
Oestrogen and progesterone have specific receptors in the central nervous system and are able to regulate neuronal development and plasticity, neuronal excitability, mitochondrial energy production, and neurotransmitter synthesis, release, and transport. On neuronal excitability, estradiol and progesterone seem to have an opposite effect, with estradiol being excitatory and progesterone and its derivative allopregnanolone being inhibitory. Estradiol augments N-methyl-d-aspartate-mediated… CONTINUE READING
Topics from this paper
Paper Mentions
68 Citations
The Impact of Gonadal Hormones on the Expression of Human Neurological Disorders
- Medicine
- Neuroendocrinology
- 2015
- 5
Effects of progesterone on glutamate transporter 2 and gamma-aminobutyric acid transporter 1 expression in the developing rat brain after recurrent seizures☆
- Chemistry, Medicine
- Neural regeneration research
- 2012
- 1
The Effects of Biological Sex and Ovarian Hormones on Exercise-Induced Neuroplasticity
- Medicine
- Neuroscience
- 2019
- 6
- PDF
Influence of Ovarian Hormones on Cortical Spreading Depression and Its Suppression by L-kynurenine in Rat
- Medicine
- PloS one
- 2013
- 19
- PDF
Neuroendocrine considerations in the treatment of men and women with epilepsy
- Psychology, Medicine
- The Lancet Neurology
- 2013
- 76
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling
- Chemistry, Medicine
- Neuroscience
- 2014
- 15
Allopregnanolone as a mediator of affective switching in reproductive mood disorders
- Medicine
- Psychopharmacology
- 2014
- 61
Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study
- Medicine
- Cephalalgia : an international journal of headache
- 2020
References
SHOWING 1-10 OF 44 REFERENCES
Effects of ovarian hormones on human cortical excitability
- Chemistry, Medicine
- Annals of neurology
- 2002
- 244
GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
- Biology
- Nature
- 1998
- 502
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid.
- Medicine
- Nature
- 1998
- 182
The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: Implications for diagnosis and treatment
- Psychology, Medicine
- Epilepsy & Behavior
- 2008
- 29
- Highly Influential
Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect
- Biology, Medicine
- Brain Research
- 1989
- 186
Pathogenesis in Menstrual Cycle‐Linked CNS Disorders
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 2003
- 144
Withdrawal properties of a neuroactive steroid: implications for GABAA receptor gene regulation in the brain and anxiety behavior
- Chemistry, Medicine
- Steroids
- 2002
- 89
Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms.
- Biology, Medicine
- Journal of applied physiology
- 2001
- 587