Female premenopausal fracture risk is associated with gc phenotype.

  title={Female premenopausal fracture risk is associated with gc phenotype.},
  author={Anna Lis Lauridsen and Peter Vestergaard and Anne Pernille Hermann and Holger Jon Moller and Leif Mosekilde and Ebba Nexo},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={19 6},
UNLABELLED The phenotype of the vitamin D binding and macrophage activating protein, Gc, is a predictor of premenopausal bone fracture risk, possibly mediated through activation of osteoclasts. This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years). INTRODUCTION The multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, or vitamin D binding protein (DBP), has two functions with relation to bone tissue: it is… CONTINUE READING
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