Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence.

@article{Ebert1998FemaleGA,
  title={Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence.},
  author={Steven N Ebert and Xuekun Liu and Raymond L Woosley},
  journal={Journal of women's health},
  year={1998},
  volume={7 5},
  pages={
          547-57
        }
}
One of the most pronounced gender-based differences in response to drugs is women's far greater risk of developing the life-threatening ventricular arrhythmia called torsades de pointes (TdP). A review of the literature and databases of the Food and Drug Administration reveals that a much higher percentage of women than men develop TdP arrhythmias after taking a variety of drugs, such as antihistamines (terfenadine, astemizole), antibiotics (erythromycin), antimalarials (halofantrine… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 104 CITATIONS, ESTIMATED 57% COVERAGE

Sex differences in the mechanisms underlying long QT syndrome.

  • American journal of physiology. Heart and circulatory physiology
  • 2014
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Long QT syndrome and torsade de pointes after anthracycline chemotherapy

  • Ecancermedicalscience
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles.

  • American journal of physiology. Heart and circulatory physiology
  • 2006
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations