Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol

@article{Aubin2008FemaleRF,
  title={Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol},
  author={M Aubin and Claude Lajoie and Robert Cl{\'e}ment and Hugues Gosselin and Angelino Calderone and Louis P Perrault},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={325},
  pages={961 - 968}
}
It remains presently unknown whether vascular reactivity is impaired and whether maladaptive cardiac remodeling occurs before the onset of overt obesity and in the absence of hyperlipidemia. Normal female rats were fed a high-fat diet for 8 weeks and were associated with a modest nonsignificant increase of body weight (standard diet, 300 ± 10, versus high-fat diet, 329 ± 14 g) and a normal plasma lipid profile. In rats fed a high-fat diet, systolic (171 ± 7 mm Hg) and diastolic blood pressures… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.
  • N. Erdei, A. Tóth, +4 authors Z. Bagi
  • Chemistry, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2006
TLDR
It is suggested that, in obese rats, NO mediation of endothelium-dependent dilation of skeletal muscle arterioles is reduced because of an enhanced xanthine oxidase-derived superoxide production, which may contribute to disturbed tissue blood flow and development of increased peripheral resistance. Expand
Development of hypertension in a rat model of diet-induced obesity.
TLDR
The results suggest that hypercholesterolemia, but not hypertriglyceridemia, is linked to the diet; that hypertension and renin-angiotensin system activation are associated with obesity; and that lipid peroxidation and renal damage are the results of both factors. Expand
Oxidative Stress in a Rat Model of Obesity-Induced Hypertension
TLDR
The data show a decreased NO bioavailability in OP animals that is due in part to the increased oxidative stress, and a possible shift toward superoxide production by the enzyme. Expand
Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress.
TLDR
It is shown that early obesity is characterized by increased vascular oxidative stress and endothelial dysfunction in association with increased levels of leptin and before the development of insulin resistance and systemic oxidative stress. Expand
Protective effects of estrogen on gender-specific development of diet-induced hypertension.
TLDR
It is demonstrated that long-term consumption of HFS diet induces hypertension in both genders and is reversible by diet modification, and hormone status contributes to the delayed onset of diet-induced hypertension in females compared with males. Expand
Fatty acids increase the circulating levels of oxidative stress factors in mice with diet‐induced obesity via redox changes of albumin
TLDR
The results indicate that the increased plasma fatty acids in the high‐fat diet group resulted in the activated redox cycling of the copper–albumin complex and excessive lipid peroxidation. Expand
Elevated mean arterial pressure in the ovariectomized rat was normalized by ETA receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis
TLDR
Despite elevated blood pressure, ovariectomized rats were not associated with either cardiac hypertrophy or fibrosis and endothelin‐1, acting via the stimulation of the ETA receptor represents an integral mechanism implicated in the increase of mean arterial pressure following ovariectomy. Expand
Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit.
TLDR
A high-fat diet, even over a period as short as 12 weeks, causes fibrosis in coronary vessels as well as accumulation of collagen in the cardiac interstitium and the accumulation of cardiac collagen was associated with induction of Hcy and TGF-beta1 and with suppression of decorin. Expand
Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice.
TLDR
The characteristics of obesity induced by HFD feeding were influenced by the sex, strain and age of mice, and sex steroid hormones, hepatic lipid metabolism and systemic metabolism might be involved in these factors. Expand
Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.
TLDR
Ang II-mediated upregulation of PAI-1 and TGF-beta(1) with collagen deposition may explain the mechanism of perivascular fibrosis in obese mice. Expand
...
1
2
3
4
5
...