Female Inheritance of Malarial lap Genes Is Essential for Mosquito Transmission

  title={Female Inheritance of Malarial lap Genes Is Essential for Mosquito Transmission},
  author={J. Dale Raine and A. Ecker and Jacqui Mendoza and Rita Tewari and Rebecca R. Stanway and Robert E Sinden},
  journal={PLoS Pathogens},
  pages={209 - 212}
Members of the LCCL/lectin adhesive-like protein (LAP) family, a family of six putative secreted proteins with predicted adhesive extracellular domains, have all been detected in the sexual and sporogonic stages of Plasmodium and have previously been predicted to play a role in parasite-mosquito interactions and/or immunomodulation. In this study we have investigated the function of PbLAP1, 2, 4, and 6. Through phenotypic analysis of Plasmodium berghei loss-of-function mutants, we have… CONTINUE READING


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  • Washington (D. C.): ASM Press
  • 2005
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