Female‐specific pruritus from childhood to postmenopause: clinical features, hormonal factors, and treatment considerations

  title={Female‐specific pruritus from childhood to postmenopause: clinical features, hormonal factors, and treatment considerations},
  author={Lauren P. Rimoin and Shawn G. Kwatra and Gil Yosipovitch},
  journal={Dermatologic Therapy},
There have been considerable advances in our understanding of the pathophysiology of pruritus in recent years. The purpose of this review was to highlight itch entities in women, and in particular pruritic vulvar dermatoses that women experience among different age groups. Unique temporal shifts may contribute to the etiology of many of these conditions. These changes lead to cyclical changes in the skin's basic composition. Specifically, estrogen receptors have been detected on keratinocytes… 

Pruritus in Female Patients

  • J. Lambert
  • Medicine
    BioMed research international
  • 2014
This review aims to focus on not only itch problems specific to women, namely, pruritic vulvodermatoses, but also the specificPruritic dermatoses of pregnancy, and focuses on the diagnostic issue of these diseases.

Vulvar Pruritus: A Review of Clinical Associations, Pathophysiology and Therapeutic Management

The potential physiologic, environmental and infectious factors that contribute to the development of vulvar itch are reviewed and the importance of addressing their complex interplay when managing this disruptive and challenging symptom is emphasized.

Vulvar inflammatory disorders: A review

This review will focus only on common VID, and a few rare conditions with characteristic features such as Crohn’s disease, plasma cell vulvitis, acantholytic disorder of genitocrural area, desquamative vulVitis, and atrophic vulvovaginitis.

Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis

GRβ is highly expressed in keratinocytes of the vulvar epidermis affected by CVD, but GRβ expression was not increased in patients nonresponsive to TGC compared to responsive patients, thus, the failure mechanism in nonresponders still remains to be elucidated.

Diagnosis and Management of Vulvar Skin Disorders: ACOG Practice Bulletin, Number 224.

  • Medicine
    Obstetrics and gynecology
  • 2020
The purpose of this Practice Bulletin is to provide updated diagnostic and management recommendations for the most common vulvar skin conditions associated with inflammation: contact dermatitis, Lichen simplex chronicus, lichen sclerosus, and lichen planus.

Polymorphic eruption of pregnancy: Review of literature

Abstract Polymorphic Eruption of Pregnancy (PEP) is one of the most common dermatosis related to pregnancy. PEP usually consists of pruritic papules and plaques appearing in the third trimester of

Triggers in atopic dermatitis/eczema : separating fact from fiction : review article

An overview will be given regarding the relevant literature dealing with triggers of atopic dermatitis/eczema, which includes irritants, allergens, skin infections and others, including cigarette smoke exposure and psychological stress.

Pruritus Vulva in Adolescent Females in Arar City, KSA

There was a significant correlation between pruritus vulvae and both age group and marital status (P= 0.001) and Prevention of genitourinary infection among adolescents regarding personal hygiene is mandatory.

Spanish consensus on vulvar disorders in postmenopausal women.



Anogenital pruritus: lichen sclerosus in children.

Patients need to be monitored every 6 to 12 months even when asymptomatic because of the potential for development of malignancy and support groups and a multidisciplinary approach are recommended.

Vulval itch.

The cause of vulval itch can often be multifactorial, but with careful assessment, a primary diagnosis can be reached in most cases, and key features of the diagnosis and management of these conditions are highlighted.

Benign Vulvar Dermatoses

After completing this CME activity physicians should be better able to evaluate common vulvar skin conditions and identify these conditions as a source of significant morbidity for women.

Immunopathogenesis of recurrent vulvovaginal candidiasis

The results of both clinical studies and studies in an animal model of experimental vaginitis suggest that systemic CMI may not be the predominant host defense mechanism against C. albicans vaginal infections, and locally acquired mucosal immunity is under consideration as an important host defense at the vaginal mucosa.

Determining the Cause of Vulvovaginal Symptoms

The focus is on the clinical presentation, specifically 1) the absence or presence and characteristics of vaginal discharge; 2) the nature of sensory symptoms (itch and/or pain, localized or generalized, provoked, intermittent, or chronic); and 3) the presence or presence of mucocutaneous changes.

Dermatoses of Pregnancy - Clues to Diagnosis, Fetal Risk and Therapy

The new classification of pregnancy dermatoses is discussed in detail, a practical algorithm to facilitate the management of the pregnant patient with skin lesions is presented, and clinical characteristics, in particular timing of onset, morphology and localization of skin lesions are crucial for diagnosis.

Vulval disease in pre‐pubertal girls

  • G. Fischer
  • Medicine
    The Australasian journal of dermatology
  • 2001
In this group, dermatitis, psoriasis and lichen sclerosus are the most frequently seen dermatoses and birthmarks and congenital abnormalities presenting for the first time are more of an issue in children than in adults.

Relation of lichen sclerosus et atrophicus of the vulva to development of carcinoma.

This study did not provide evidence of carcinoma arising from LS&A, but five of the 92 patients developed 6 malignant neoplasms in other sites, including carcinoma of the endometrium, lung, and simultaneous carcinomas of the colon and cervix.

The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study.

This study demonstrates an association of autoimmune disorder and autoantibodies with erosive LP of the vulva and confirms the autoimmune associations of vulval LS.

New concepts in vulvodynia.

  • L. Edwards
  • Medicine
    American journal of obstetrics and gynecology
  • 2003
Vulvodynia is chronic vulvar burning/pain without clear medical findings and health care professionals should thoroughly rule out specific, treatable causes or factors such as dermatoses or group B Streptococcus infections.