Fellow travellers: emergent properties of collective cell migration

@article{Rrth2012FellowTE,
  title={Fellow travellers: emergent properties of collective cell migration},
  author={P. R{\o}rth},
  journal={EMBO reports},
  year={2012},
  volume={13}
}
  • P. Rørth
  • Published 2012
  • Biology, Medicine
  • EMBO reports
Cells can migrate individually or collectively. Collective movement is common during normal development and is also a characteristic of some cancers. This review discusses recent insights into features that are unique to collective cell migration, as well as properties that emerge from these features. The first feature is that cells of the collective affect each other through adhesion, force‐dependent and signalling interactions. The second feature is that cells of the collective differ from… Expand

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References

SHOWING 1-10 OF 90 REFERENCES
Collective guidance of collective cell migration.
  • P. Rørth
  • Biology, Medicine
  • Trends in cell biology
  • 2007
TLDR
This work proposes a model for how a group of cells can process and react to guidance information as a unit rather than as a gathering of solitary cells and suggests that collective-guidance signaling occurs alongside individual cell reactions. Expand
Whence directionality: guidance mechanisms in solitary and collective cell migration.
  • P. Rørth
  • Biology, Medicine
  • Developmental cell
  • 2011
TLDR
The relationship between guidance input and the cellular output is discussed, considering effects from classical chemotaxis to contact-dependent guidance, and the influences of membrane trafficking and of imposed constraints on directional movement are considered. Expand
Collective cell migration in development
  • C. Weijer
  • Biology, Medicine
  • Journal of Cell Science
  • 2009
Collective cell migration is a key process during the development of most organisms. It can involve either the migration of closely packed mesenchymal cells that make dynamic contacts with frequentlyExpand
Plithotaxis and emergent dynamics in collective cellular migration.
TLDR
In a broad range of epithelial and endothelial cell sheets, collective cell migration is governed instead by a newly discovered emergent mechanism of innately collective cell guidance - plithotaxis. Expand
Collective cell migration in morphogenesis, regeneration and cancer
TLDR
Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research. Expand
Two distinct modes of guidance signalling during collective migration of border cells
TLDR
Genetic analysis combined with live imaging shows that polarized cell behaviour is critical for the initial phase of migration, whereas dynamic collective behaviour dominates later, and information processing at the multicellular level is used to guide collective behaviour of a cell group. Expand
Effective guidance of collective migration based on differences in cell states
TLDR
Differences in cell signaling states are sufficient to direct collective migration and are likely a substantial contributor to normal guidance, according to factors normally considered when analyzing eukaryotic cell guidance. Expand
Collective Chemotaxis Requires Contact-Dependent Cell Polarity
TLDR
A role for N-cadherin during contact inhibition of locomotion is shown and a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis is revealed, whereby attractants such as Sdf1 amplify and stabilize contact-dependent cell polarity, resulting in directional collective migration. Expand
Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration
TLDR
It is proposed that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents. Expand
Orientation and polarity in collectively migrating cell structures: statics and dynamics.
TLDR
Working with epithelial Madin-Darby canine kidney monolayers, it is shown that cells within the fingers, as compared with the epithelium, are well oriented and polarized along the main finger direction, which suggests that these cells actively migrate. Expand
...
1
2
3
4
5
...