Feline leukemia virus envelope sequences that affect T-cell tropism and syncytium formation are not part of known receptor-binding domains.

@article{Gwynn2000FelineLV,
  title={Feline leukemia virus envelope sequences that affect T-cell tropism and syncytium formation are not part of known receptor-binding domains.},
  author={S R Gwynn and F. Claire Hankenson and Adam S Lauring and Jennifer Rohn and Julie M Overbaugh},
  journal={Journal of virology},
  year={2000},
  volume={74 13},
  pages={5754-61}
}
The envelope protein is a primary pathogenic determinant for T-cell-tropic feline leukemia virus (FeLV) variants, the best studied of which is the immunodeficiency-inducing virus, 61C. We have previously demonstrated that T-cell-tropic, cytopathic, and syncytium-inducing viruses evolve in cats infected with a relatively avirulent, transmissible form of FeLV, 61E. The envelope gene of an 81T variant, which encoded scattered single-amino-acid changes throughout the envelope as well as a 4-amino… CONTINUE READING

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