Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats.

@article{Pedersen2012FelineIP,
  title={Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats.},
  author={Niels C Pedersen and Hongwei Liu and Jennifer Scarlett and Christian M. Leutenegger and Lyudmila Golovko and Heather Lynne Kennedy and Farina Mustaffa Kamal},
  journal={Virus research},
  year={2012},
  volume={165 1},
  pages={
          17-28
        }
}
Feline infectious peritonitis virus (FIPV) was presumed to arise from mutations in the 3c of a ubiquitous and largely nonpathogenic feline enteric coronavirus (FECV). However, a recent study found that one-third of FIPV isolates have an intact 3c and suggested that it is not solely involved in FIP but is essential for intestinal replication. In order to confirm these assumptions, 27 fecal and 32 FIP coronavirus isolates were obtained from resident or adopted cats from a large metropolitan… CONTINUE READING
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