Feline immunodeficiency virus neurotropism: evidence that astrocytes and microglia are the primary target cells.

@article{Dow1992FelineIV,
  title={Feline immunodeficiency virus neurotropism: evidence that astrocytes and microglia are the primary target cells.},
  author={Steven W Dow and Matthew J. Dreitz and Edward A. Hoover},
  journal={Veterinary immunology and immunopathology},
  year={1992},
  volume={35 1-2},
  pages={
          23-35
        }
}
To investigate the neuropathogenesis of feline immunodeficiency virus (FIV) infection in vitro, we have utilized three populations of cultured feline neural cells (astrocytes, microglia, brain endothelium) to assess the relative susceptibility to FIV infection, ability to produce viral antigens, and effects of infection on cell survival. Astrocytes appeared to be the most susceptible to infection, followed by microglia, whereas brain endothelial cells were relatively resistant to infection… CONTINUE READING
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