Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5'-triphosphate-loaded erythrocytes.

@article{Magnani1994FelineIV,
  title={Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5'-triphosphate-loaded erythrocytes.},
  author={Matteo Magnani and Luiga Rossi and Alessandra Fraternale and Lucia Silvotti and Fausto Quintavalla and Giuseppe Piedimonte and Donatella Matteucci and Fulvia Baldinotti and Mauro Bendinelli},
  journal={AIDS research and human retroviruses},
  year={1994},
  volume={10 9},
  pages={1179-86}
}
Although HIV-1 and other mammalian lentiviruses infect macrophages, they are not cytopathic. Consequently, these infected long-lived cells serve as major virus reservoirs with a key role in the propagation of the virus throughout the body as well as in the pathogenesis of AIDS. Furthermore, well-differentiated macrophages possess low abilities to phosphorylate the most common reverse transcriptase inhibitors of the nucleoside analog family. In an attempt to overcome these problems we have… CONTINUE READING