Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis.

@article{Tompkins2002FelineIV,
  title={Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis.},
  author={Mary B. Tompkins and Marta E Bull and Janet L Dow and Judith M. Ball and Ellen W. Collisson and Barbara J Winslow and Anagha P. Phadke and Thomas W. Vahlenkamp and Wayne A. F. Tompkins},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 8},
  pages={
          1077-93
        }
}
The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 and cytotoxic T lymphocyte antigen 4 (CTLA4) on T cells. CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune response. Because T cell apoptosis and immunodeficiency is a characteristic of feline immunodeficiency virus (FIV)-infected cats, it is possible that negative T cell signaling via B7 and CTLA4 may… CONTINUE READING

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