Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins.

@article{Sundstrom2008FelineIV,
  title={Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins.},
  author={Magnus Sundstrom and Udayan Chatterji and Lana Schaffer and Sohela de Roz{\`i}eres and John H. Elder},
  journal={Virology},
  year={2008},
  volume={371 2},
  pages={394-404}
}
Expression of the feline immunodeficiency virus (FIV) accessory protein OrfA (or Orf2) is critical for efficient viral replication in lymphocytes, both in vitro and in vivo. OrfA has been reported to exhibit functions in common with the human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) accessory proteins Vpr and Tat, although the function of OrfA has not been fully explained. Here, we use microarray analysis to characterize how OrfA modulates the gene expression profile… CONTINUE READING

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