Corpus ID: 27193343

Feline coronaviruses associated with feline infectious peritonitis have modifications to spike protein activation sites at two discrete positions

@article{Licitra2014FelineCA,
  title={Feline coronaviruses associated with feline infectious peritonitis have modifications to spike protein activation sites at two discrete positions},
  author={Beth N. Licitra and Kelly L. Sams and Donald W. Lee and Gary R.Whittaker},
  journal={arXiv: Genomics},
  year={2014}
}
  • Beth N. Licitra, Kelly L. Sams, +1 author Gary R.Whittaker
  • Published 2014
  • Biology
  • arXiv: Genomics
  • Feline infectious peritonitis (FIP) is associated with mutations in the feline coronavirus (FCoV) genome that are thought to convert the subclinical feline enteric coronavirus (FECV) into the lethal feline infectious peritonitis virus (FIPV). A key feature of FIPV, not shared with FECV, is the productive infection of macrophages. Therefore mutations in proteins that govern cell tropism, such as the spike glycoprotein, may play an important role in FIP progression. In a prior study, involving a… CONTINUE READING

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