Feline Calicivirus VP2 Is Essential for the Production of Infectious Virions

@article{Sosnovtsev2005FelineCV,
  title={Feline Calicivirus VP2 Is Essential for the Production of Infectious Virions},
  author={S. Sosnovtsev and G. Belliot and Kyeong-Ok Chang and Oge C Onwudiwe and K. Green},
  journal={Journal of Virology},
  year={2005},
  volume={79},
  pages={4012 - 4024}
}
ABSTRACT The third open reading frame (ORF3) located at the 3′ end of the genomic RNA of feline calicivirus (FCV) encodes a small (12.2-kDa) minor structural protein of 106 amino acids designated VP2. Point mutations and deletions were introduced into an infectious FCV cDNA clone in order to evaluate the functional importance of ORF3 and its encoded protein, VP2. Deletion of the entire ORF3 sequence was lethal for the virus, and evidence was found for strong selective pressure to produce the… Expand
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