Felbamate for partial seizures

@article{Leppik1991FelbamateFP,
  title={Felbamate for partial seizures},
  author={Ilo Leppik and Fritz E. Dreifuss and Gordon W. Pledger and Nina M. Graves and Nancy Santilli and Ivo Drury and J. Y. Tsay and Margaret P. Jacobs and Ed Bertram and James J. Cereghino and Gerald Cooper and J. Todd Sahlroot and Pamela Sheridan and M. R. Ashworth and S. I. Lee and Tess Sierzant},
  journal={Neurology},
  year={1991},
  volume={41},
  pages={1785 - 1785}
}
Felbamate (2-phenyl-1,3-propanediol dicarbamate) has a favorable preclinical profile in animal models of epilepsy. We present the results of a double-blind, randomized, placebo-controlled clinical trial in patients with partial seizures. Criteria for entry included a requirement for four or more partial seizures per month despite concomitant therapeutic blood levels of phenytoin and carbamazepine. Fifty-six patients (mean age, 31.4 years; 32 men, 24 women) completed the trial. The mean seizure… 

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References

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TLDR
A randomized, double‐blind, three‐period cross‐over study of felbamate (FBM, 2‐phenyl‐l,3‐propanediol dicarbamate: Carter‐Wallace 554) in patients with complex partial seizures suggested a strong antiseizure effect of FBM.
Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats
TLDR
Felbamate is a relatively nontoxic agent with a unique profile of anticonvulsant action and is effective after nontoxic oral doses in both mice and rats by the MES and s.c. PTZ tests.
Felbamate Increases Phenytoin but Decreases Carbamazepine Concentrations
TLDR
Felbamate (FBM), a novel antiepileptic drug, was observed to have opposite effects on the serum concentrations of phenytoin (PHT) and carbamazepine (CBZ), highlighting the need for evaluating pharmacokinetic interactions before major drug trials.
Effect of Felbamate on Phenytoin and Carbamazepine Serum Concentrations
TLDR
Felbamate apparently causes a bidirectional effect on the serum concentrations of PHT and CBZ when all three drugs are taken concomitantly.
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TLDR
The results of this study indicate that PGB was not a potent antiepileptic drug in this population of persons with intractable epilepsy.
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TLDR
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TLDR
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Abstract Many of the more useful and powerful nonparametric procedures may be presented in a unified manner by treating them as rank transformation procedures. Rank transformation procedures are ones
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