Feeding of palm oil carotene to mice did not modify X-ray-induced chromosomal damage in bone marrow cells.

  title={Feeding of palm oil carotene to mice did not modify X-ray-induced chromosomal damage in bone marrow cells.},
  author={Keizo Umegaki and S Hirota and Masahiro Aoshima and S Aoki and Takatoshi Esashi},
  journal={Journal of nutritional science and vitaminology},
  volume={41 1},
The influence of palm oil carotene treatment on X-ray-induced chromosomal damage in bone marrow cells of mice was studied. Palm oil carotene contains alpha- and beta-carotene in a ratio of 1:3. Mice were fed either a basal diet or carotene diet containing 50 mg of palm oil carotene/100 g for 15 days. On day 13, mice to be X-ray-irradiated received 0.5 Gy of X-ray to their whole bodies, and the chromosomal damage in bone marrow cells was evaluated in terms of the percentages of micronucleated… 
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Feeding mice palm carotene prevents DNA damage in bone marrow and reduction of peripheral leukocyte counts, and enhances survival following X-ray irradiation.

It is suggested that feeding mice palm carotene prevents radiation-induced damages by way of its antioxidant activity and/or vitamin A activity and the survival of mice that received whole-body X-ray irradiation.

Antioxidative Nutrients and Oxidative DNA Damage

The relationship between oxidative DNA damage and antioxidants in foods is reported, and information about the relationship is presented, including analytical methods for assessing DNA damageand antioxidants in human samples.



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Carotenoids and cancer in animal models.

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Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice.

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Plasma vitamin A levels were not altered by any of the dietary lipids or by an excess of vitamin E, and the concentrations of β‐carotene in plasma were the lowest in ra...

The metabolism of [14C]β-carotene and the presence of other carotenoids in rats and monkeys.

The metabolism of beta-carotene has been studied in both rats and Rhesus monkeys, following the oral administration of [14C]beta-carotene in olive oil supplemented with 1 mg/mL alpha-tocopherol. In

Use of the micronucleus test to monitor the effect of vitamin A, beta‐carotene and canthaxanthin on the buccal mucosa of betel nut/tobacco chewers

The lack of protective activity of canthaxanthin, which is a good trapper of oxygen singlets but cannot be converted into vitamin A, suggests that vitamin A and beta‐carotene exert their inhibitory effect on the formation of micronuclei by a mechanism not involving the scavenging of free radicals.